Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT‐1 in striatum of asymptomatic volunteers and patients with Parkinson's disease
Identifieur interne : 004056 ( Main/Exploration ); précédent : 004055; suivant : 004057Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT‐1 in striatum of asymptomatic volunteers and patients with Parkinson's disease
Auteurs : David R. Lynch [États-Unis] ; P. David Mozley [États-Unis] ; Set Sokol [États-Unis] ; Nicole M. C. Maas [États-Unis] ; Laura J. Balcer [États-Unis] ; Andrew D. Siderowf [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Catechol O-Methyltransferase (genetics), Catecholamine, Corpus Striatum (radionuclide imaging), Corpus striatum, Disease Progression, Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Dopamine agonist, Early Diagnosis, Emission tomography, Female, Genetic Variation, Genotype, Human, Humans, Image Processing, Computer-Assisted, Male, Membrane Glycoproteins, Membrane Transport Proteins (genetics), Metabolism, Middle Aged, Minisatellite Repeats, Monoamine Oxidase (genetics), Nerve Tissue Proteins, Organotechnetium Compounds (diagnostic use), PET, Parkinson Disease (genetics), Parkinson Disease (radionuclide imaging), Parkinson disease, Polymerase Chain Reaction, Polymorphism, Polymorphism, Genetic (genetics), Positron, Radiopharmaceuticals (diagnostic use), Reference Values, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), genetic risk, parkinsonism, polymorphism.
- MESH :
- chemical , diagnostic use : Organotechnetium Compounds, Radiopharmaceuticals, Tropanes.
- chemical , genetics : Catechol O-Methyltransferase, Membrane Transport Proteins, Monoamine Oxidase.
- chemical , metabolism : Dopamine.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- radionuclide imaging : Corpus Striatum, Parkinson Disease.
- Adolescent, Adult, Aged, Aged, 80 and over, Disease Progression, Dopamine Plasma Membrane Transport Proteins, Early Diagnosis, Female, Genetic Variation, Genotype, Humans, Image Processing, Computer-Assisted, Male, Membrane Glycoproteins, Middle Aged, Minisatellite Repeats, Nerve Tissue Proteins, Polymerase Chain Reaction, Reference Values, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon.
Abstract
SPECT scanning using 99Tc‐TRODAT‐1, a ligand that binds to dopamine transporters, may be useful for detection of early Parkinson's disease (PD), diagnosis of presymptomatic individuals, and monitoring disease progression. Understanding whether genetic factors contribute to inter‐individual variability is crucial for interpreting imaging results in the context of disease pathophysiology. We tested whether polymorphisms in the genes for catechol‐O‐methyltransferase (COMT), monoamine‐oxidase B (MAO‐B), and the dopamine transporter (DAT) influence dopamine uptake parameters in the striatum in vivo in asymptomatic volunteers and patients with PD as measured with 99Tc‐TRODAT‐1. 99Tc‐TRODAT‐1 binding declined with age in both asymptomatic volunteers and PD patients, and depended on disease duration in PD patients. We found no significant association between COMT, MAO‐B, and DAT polymorphisms and results of 99Tc‐TRODAT‐1 testing in asymptomatic volunteers or patients with PD. In PD patients, the age of disease onset and speed of progression did not differ based on these polymorphisms. These results demonstrate that these specific genetic variations do not alter the fidelity of 99Tc‐TRODAT‐1 as a measure of dopaminergic function in asymptomatic volunteer individuals or patients with PD. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10430
Affiliations:
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Le document en format XML
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David Mozley</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sokol, Set" sort="Sokol, Set" uniqKey="Sokol S" first="Set" last="Sokol">Set Sokol</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Maas, Nicole M C" sort="Maas, Nicole M C" uniqKey="Maas N" first="Nicole M. C." last="Maas">Nicole M. C. Maas</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J." last="Balcer">Laura J. Balcer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Siderowf, Andrew D" sort="Siderowf, Andrew D" uniqKey="Siderowf A" first="Andrew D." last="Siderowf">Andrew D. Siderowf</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pennsylvania and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-07">2003-07</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="804">804</biblScope><biblScope unit="page" to="812">812</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">117E05FDD932CE8C1DB40D09EEDAA0FAF3E58653</idno><idno type="DOI">10.1002/mds.10430</idno><idno type="ArticleID">MDS10430</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Catechol O-Methyltransferase (genetics)</term><term>Catecholamine</term><term>Corpus Striatum (radionuclide imaging)</term><term>Corpus striatum</term><term>Disease Progression</term><term>Dopamine</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Dopamine agonist</term><term>Early Diagnosis</term><term>Emission tomography</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Human</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins (genetics)</term><term>Metabolism</term><term>Middle Aged</term><term>Minisatellite Repeats</term><term>Monoamine Oxidase (genetics)</term><term>Nerve Tissue Proteins</term><term>Organotechnetium Compounds (diagnostic use)</term><term>PET</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson disease</term><term>Polymerase Chain Reaction</term><term>Polymorphism</term><term>Polymorphism, Genetic (genetics)</term><term>Positron</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Reference Values</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term><term>genetic risk</term><term>parkinsonism</term><term>polymorphism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Organotechnetium Compounds</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Catechol O-Methyltransferase</term><term>Membrane Transport Proteins</term><term>Monoamine Oxidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Early Diagnosis</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Membrane Glycoproteins</term><term>Middle Aged</term><term>Minisatellite Repeats</term><term>Nerve Tissue Proteins</term><term>Polymerase Chain Reaction</term><term>Reference Values</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Catécholamine</term><term>Corps strié</term><term>Dopamine</term><term>Homme</term><term>Métabolisme</term><term>Parkinson maladie</term><term>Polymorphisme</term><term>Positon</term><term>Stimulant dopaminergique</term><term>Tomoscintigraphie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SPECT scanning using 99Tc‐TRODAT‐1, a ligand that binds to dopamine transporters, may be useful for detection of early Parkinson's disease (PD), diagnosis of presymptomatic individuals, and monitoring disease progression. Understanding whether genetic factors contribute to inter‐individual variability is crucial for interpreting imaging results in the context of disease pathophysiology. We tested whether polymorphisms in the genes for catechol‐O‐methyltransferase (COMT), monoamine‐oxidase B (MAO‐B), and the dopamine transporter (DAT) influence dopamine uptake parameters in the striatum in vivo in asymptomatic volunteers and patients with PD as measured with 99Tc‐TRODAT‐1. 99Tc‐TRODAT‐1 binding declined with age in both asymptomatic volunteers and PD patients, and depended on disease duration in PD patients. We found no significant association between COMT, MAO‐B, and DAT polymorphisms and results of 99Tc‐TRODAT‐1 testing in asymptomatic volunteers or patients with PD. In PD patients, the age of disease onset and speed of progression did not differ based on these polymorphisms. These results demonstrate that these specific genetic variations do not alter the fidelity of 99Tc‐TRODAT‐1 as a measure of dopaminergic function in asymptomatic volunteer individuals or patients with PD. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R." last="Lynch">David R. Lynch</name></region><name sortKey="Balcer, Laura J" sort="Balcer, Laura J" uniqKey="Balcer L" first="Laura J." last="Balcer">Laura J. Balcer</name><name sortKey="Lynch, David R" sort="Lynch, David R" uniqKey="Lynch D" first="David R." last="Lynch">David R. Lynch</name><name sortKey="Maas, Nicole M C" sort="Maas, Nicole M C" uniqKey="Maas N" first="Nicole M. C." last="Maas">Nicole M. C. Maas</name><name sortKey="Mozley, P David" sort="Mozley, P David" uniqKey="Mozley P" first="P. David" last="Mozley">P. David Mozley</name><name sortKey="Siderowf, Andrew D" sort="Siderowf, Andrew D" uniqKey="Siderowf A" first="Andrew D." last="Siderowf">Andrew D. Siderowf</name><name sortKey="Sokol, Set" sort="Sokol, Set" uniqKey="Sokol S" first="Set" last="Sokol">Set Sokol</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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